Publications

2022

S Xue*, TTN Ly, RS Vijayakar, J Chen, J Ng, AS Mathuru, F Magdinier & B Reversade* HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring. Nature Communications 13, (2022) 3583. https://doi.org/10.1038/s41467-022-31185-8 News Highlight

AS Mathuru*, A Vyas. Social plasticity and decision making. Brain Res. 2022 Jun 15;1785:147890. doi: 10.1016/j.brainres.2022.147890 

A Gemmer, K Mirkes, L Anneser, T Eilers, C Kibat,  AS Mathuru, S Ryu, E Schuman Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio). Sci Rep 12, 4322. https://doi.org/10.1038/s41598-022-07990-y

FM Nathan, C Kibat, T Goel, J Stewart, A Claridge-Chang, AS Mathuru* Contingent stimulus delivery assay for zebrafish reveals a role for CCSER1 in alcohol preference  Addiction Biology DOI: https://doi.org/10.1111/adb.13126 News Highlight

2021

SH Tay, E Elliyana, Y Le, S Menachem, J Ohmer,  AS Mathuru, U Fischer, and C Winkler* A novel zebrafish model for intermediate type spinal muscular atrophy demonstrates the importance of Smn for maintenance of mature motor neurons. Human Molecular Genetics DOI: https://doi.org/10.1093/hmg/ddab212(2021) 

PV AshaRani, Syidda Amron, Noor Azizah Bte Zainuldin, Sumanty Tohari, Alvin YJ Ng, Guo Song, Byrappa Venkatesh*, AS Mathuru* Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot Feasibility Study. J. Clin. Med. 10(13), 2810; https://doi.org/10.3390/jcm10132810

Wen Kin Lim, Prameet Kaur, Huanyan Huang, Richard Shim Jo, Anupriya Ramamoorthy, Li Fang Ng, Jahnavi Suresh, Fahrisa Islam Maisha, AS Mathuru, Nicholas S Tolwinski Optogenetic approaches for understanding homeostatic and degenerative processes in Drosophila, Cellular and Molecular Life Sciences 78, 5865–5880 (2021). https://doi.org/10.1007/s00018-021-03836-4

Angela Koh, Shijie Tao, Goh Yun Jing, Vindhya Chaganty, Kelvin See, Kathiresan Purushothaman, László Orbán, AS Mathuru, Thorsten Wohland, Christoph Winkler, A Neurexin2aa deficiency results in axon pathfinding defects and increased anxiety in zebrafish, Human Molecular Genetics, ddaa260, 2020 https://doi.org/10.1093/hmg/ddaa260

Wong HH, Seet SH, Maier M, Gurel A, Traspas RM, Lee C, et al. Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen storage-associated mitochondriopathy. Am J Hum Genet. 2021. https://www.sciencedirect.com/science/article/pii/S0002929721001877

2020

Kaur P, Kibat C, Teo E, Gruber J, AS Mathuru, and Nicholas S Tolwinski Use of Optogenetic Amyloid-β to Monitor Protein Aggregation in Drosophila melanogaster, Danio rerio, and Caenorhabditis elegans Bio-protocol 10 (23): e3856. DOI: https://doi.org/10.21769/bioprotoc.3856

S Jesuthasan*#, S Krishnan#, RK Cheng, and AS Mathuru*. Neural correlates of state transitions elicited by a chemosensory danger cue. Progress in Neuropsychopharmacology & Biological Psychiatry, 2020 110110. http://doi.org/10.1016/j.pnpbp.2020.110110

M Vitkauskas and AS Mathuru*, 2020. Total Recall: Lateral Habenula and Psychedelics in the Study of Depression and Comorbid Brain Disorders. International Journal of Molecular Sciences, 2020, 21(18), 6525–17. http://doi.org/10.3390/ijms21186525

AS Mathuru*, F Libersat, A Vyas, S Teseo Why behavioral neuroscience still needs diversity?: A curious case of a persistent need Neuroscience & Biobehavioral Reviews, 2020 https://doi.org/10.1016a/j.neubiorev.2020.06.021 

CH Lim, P Kaur, et al. AS Mathuru, and N Tolwinski Application of Optogenetic Amyloid-β Distinguishes Between Metabolic and Physical Damage in Neurodegeneration. eLife, 2020, https://doi.org/10.7554/eLife.52589

WK Lim and AS Mathuru* Design, challenges, and the potential of transcriptomics to understand social behavior, Current Zoology, 2020. https://doi.org/10.1093/cz/zoaa007  

Hengel and Bosso-Lefèvre et al. Loss-of-function Mutations in UDP-Glucose 6-Dehydrogenase Cause Recessive Developmental Epileptic Encephalopathy, Nature Communications, 2020. https://doi.org/10.1038/s41467-020-14360-7.

2019

MT Stamps, S Go & AS Mathuru* Computational geometric tools for quantitative comparison of locomotory behavior. Scientific Reports, 2019 DOI: https://doi.org/10.1038/s41598-019-52300-8

S Haghani, M Karia, RK Cheng & AS Mathuru* An automated assay system to study novel tank induced anxiety Front. Behav. Neuroscience, 2019 DOI: https://doi.org/10.3389/fnbeh.2019.00180

2018

C Lim & AS Mathuru*. Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems. J. Dev. Biol. 2018, 6(1), 1, 2018 DOI: https://doi.org/10.3390/jdb6010001

Xu, C., Govindarajan, L.N., Zhang, Y. et al. Int Journal of Computer Vision, 2018 126: 897, 2018, https://doi.org/10.1007/s11263-018-1069-3

AS Mathuru* A little rein on addiction Seminars in Cell & Developmental Biology,  78, 120-129, 2018, DOI: https://doi.org/10.1016/j.semcdb.2017.09.030

2017

(Pre-print) AS Mathuru* et al. Familiarity with companions aids recovery from fear in zebrafish. BioRxiv, 2017 doi: https://doi.org/10.1101/098509

2016

AS Mathuru* Conspecific injury raises an alarm in medaka. Scientific Reports, Volume 6, Article number: 36615, 2016 DOI: http://dx.doi.org/10.1038/srep36615

2010-2014

S Krishnan#, AS Mathuru# et al. The right dorsal habenula limits attraction to specific odors. Current Biology, 2014,DOI: http://dx.doi.org/10.1016/j.cub.2014.03.073 (# equal contribution)

SJ Tan, M Kee, AS Mathuru et al. A microfluidic device to sort cells based on dynamic response to a stimulus, PLOS One, 2013, DOI: http://dx.doi.org/10.1371/journal.pone.0078261

A Schirmer, S Jesuthasan and AS Mathuru* Tactile stimuli reduce fear in fish, Front. of Behav. Neurosci., 2013, DOI: http://dx.doi.org/10.3389/fnbeh.2013.00167

AS Mathuru and S Jesuthasan The medial habenula as a regulator of anxiety in adult zebrafish. Front. Neural Circuits 2013, DOI: http://dx.doi.org/10.3389/fncir.2013.00099

AS Mathuru et. al., Chondroitin Fragments Are Odorants that trigger fear behavior in fish. Current Biology, 2012 DOI: http://dx.doi.org/10.1016/j.cub.2012.01.061

A Lee, AS Mathuru, et. al., The habenula prevents helpless behavior in larval zebrafish. Current Biology, 2010 DOI: http://dx.doi.org/10.1016/j.cub.2010.11.025

2006-2010

AS Mathuru and S Jesuthasan, Alarm Response in Zebrafish: Innate Fear in a Vertebrate Genetic Model. Journal of Neurogenetics, 2008 DOI: 10.1080/01677060802298475

M Hendricks, AS Mathuru et al. Disruption of Esrom and Ryk identifies the roof plate boundary as an intermediate target for commissure formation. Molecular and Cellular Neuroscience, 2008, DOI: http://dx.doi.org/10.1016/j.mcn.2007.10.002

AS Mathuru and US Bhalla, A propagating ERKII switch forms zones of elevated dendritic activation correlated with plasticity. HFSP J, 2006, DOI: http://dx.doi.org/10.2976/1.2721383

AS Mathuru and US Bhalla, Synaptic plasticity – in vitro and in silico : Insights into an intracellular signaling maze. Physiology, 2006 DOI: 10.1152/physiol.00009.2006

2002-2006

AS Mathuru and US Bhalla, A role for ERKII in synaptic pattern selectivity on the time-scale of minutes. E. J. Neurosci., 2004 DOI: http://dx.doi.org/10.1111/j.1460-9568.2004.03725.x

SJ Vayttaden, Mathuru AS and US Bhalla, A spectrum of models of signaling pathways. Chembiochem, 2004, DOI: 10.1002/cbic.200400127