S Xue*, TTN Ly, RS Vijayakar, J Chen, J Ng, AS Mathuru, F Magdinier & B Reversade* HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring. Nature Communications 13, (2022) 3583. News Highlight

AS Mathuru*, A Vyas. Social plasticity and decision making. Brain Res. 2022 Jun 15;1785:147890. doi: 10.1016/j.brainres.2022.147890 

A Gemmer, K Mirkes, L Anneser, T Eilers, C Kibat,  AS Mathuru, S Ryu, E Schuman Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio). Sci Rep 12, 4322.

FM Nathan, C Kibat, T Goel, J Stewart, A Claridge-Chang, AS Mathuru* Contingent stimulus delivery assay for zebrafish reveals a role for CCSER1 in alcohol preference  Addiction Biology DOI: News Highlight


SH Tay, E Elliyana, Y Le, S Menachem, J Ohmer,  AS Mathuru, U Fischer, and C Winkler* A novel zebrafish model for intermediate type spinal muscular atrophy demonstrates the importance of Smn for maintenance of mature motor neurons. Human Molecular Genetics DOI: 

PV AshaRani, Syidda Amron, Noor Azizah Bte Zainuldin, Sumanty Tohari, Alvin YJ Ng, Guo Song, Byrappa Venkatesh*, AS Mathuru* Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot Feasibility Study. J. Clin. Med. 10(13), 2810;

Wen Kin Lim, Prameet Kaur, Huanyan Huang, Richard Shim Jo, Anupriya Ramamoorthy, Li Fang Ng, Jahnavi Suresh, Fahrisa Islam Maisha, AS Mathuru, Nicholas S Tolwinski Optogenetic approaches for understanding homeostatic and degenerative processes in Drosophila, Cellular and Molecular Life Sciences 78, 5865–5880 (2021).

Angela Koh, Shijie Tao, Goh Yun Jing, Vindhya Chaganty, Kelvin See, Kathiresan Purushothaman, László Orbán, AS Mathuru, Thorsten Wohland, Christoph Winkler, A Neurexin2aa deficiency results in axon pathfinding defects and increased anxiety in zebrafish, Human Molecular Genetics, ddaa260, 2020

Wong HH, Seet SH, Maier M, Gurel A, Traspas RM, Lee C, et al. Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen storage-associated mitochondriopathy. Am J Hum Genet. 2021.


Kaur P, Kibat C, Teo E, Gruber J, AS Mathuru, and Nicholas S Tolwinski Use of Optogenetic Amyloid-β to Monitor Protein Aggregation in Drosophila melanogaster, Danio rerio, and Caenorhabditis elegans Bio-protocol 10 (23): e3856. DOI:

S Jesuthasan*#, S Krishnan#, RK Cheng, and AS Mathuru*. Neural correlates of state transitions elicited by a chemosensory danger cue. Progress in Neuropsychopharmacology & Biological Psychiatry, 2020 110110.

M Vitkauskas and AS Mathuru*, 2020. Total Recall: Lateral Habenula and Psychedelics in the Study of Depression and Comorbid Brain Disorders. International Journal of Molecular Sciences, 2020, 21(18), 6525–17.

AS Mathuru*, F Libersat, A Vyas, S Teseo Why behavioral neuroscience still needs diversity?: A curious case of a persistent need Neuroscience & Biobehavioral Reviews, 2020 

CH Lim, P Kaur, et al. AS Mathuru, and N Tolwinski Application of Optogenetic Amyloid-β Distinguishes Between Metabolic and Physical Damage in Neurodegeneration. eLife, 2020,

WK Lim and AS Mathuru* Design, challenges, and the potential of transcriptomics to understand social behavior, Current Zoology, 2020.  

Hengel and Bosso-Lefèvre et al. Loss-of-function Mutations in UDP-Glucose 6-Dehydrogenase Cause Recessive Developmental Epileptic Encephalopathy, Nature Communications, 2020.


MT Stamps, S Go & AS Mathuru* Computational geometric tools for quantitative comparison of locomotory behavior. Scientific Reports, 2019 DOI:

S Haghani, M Karia, RK Cheng & AS Mathuru* An automated assay system to study novel tank induced anxiety Front. Behav. Neuroscience, 2019 DOI:


C Lim & AS Mathuru*. Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems. J. Dev. Biol. 2018, 6(1), 1, 2018 DOI:

Xu, C., Govindarajan, L.N., Zhang, Y. et al. Int Journal of Computer Vision, 2018 126: 897, 2018,

AS Mathuru* A little rein on addiction Seminars in Cell & Developmental Biology,  78, 120-129, 2018, DOI:


(Pre-print) AS Mathuru* et al. Familiarity with companions aids recovery from fear in zebrafish. BioRxiv, 2017 doi:


AS Mathuru* Conspecific injury raises an alarm in medaka. Scientific Reports, Volume 6, Article number: 36615, 2016 DOI:


S Krishnan#, AS Mathuru# et al. The right dorsal habenula limits attraction to specific odors. Current Biology, 2014,DOI: (# equal contribution)

SJ Tan, M Kee, AS Mathuru et al. A microfluidic device to sort cells based on dynamic response to a stimulus, PLOS One, 2013, DOI:

A Schirmer, S Jesuthasan and AS Mathuru* Tactile stimuli reduce fear in fish, Front. of Behav. Neurosci., 2013, DOI:

AS Mathuru and S Jesuthasan The medial habenula as a regulator of anxiety in adult zebrafish. Front. Neural Circuits 2013, DOI:

AS Mathuru et. al., Chondroitin Fragments Are Odorants that trigger fear behavior in fish. Current Biology, 2012 DOI:

A Lee, AS Mathuru, et. al., The habenula prevents helpless behavior in larval zebrafish. Current Biology, 2010 DOI:


AS Mathuru and S Jesuthasan, Alarm Response in Zebrafish: Innate Fear in a Vertebrate Genetic Model. Journal of Neurogenetics, 2008 DOI: 10.1080/01677060802298475

M Hendricks, AS Mathuru et al. Disruption of Esrom and Ryk identifies the roof plate boundary as an intermediate target for commissure formation. Molecular and Cellular Neuroscience, 2008, DOI:

AS Mathuru and US Bhalla, A propagating ERKII switch forms zones of elevated dendritic activation correlated with plasticity. HFSP J, 2006, DOI:

AS Mathuru and US Bhalla, Synaptic plasticity – in vitro and in silico : Insights into an intracellular signaling maze. Physiology, 2006 DOI: 10.1152/physiol.00009.2006


AS Mathuru and US Bhalla, A role for ERKII in synaptic pattern selectivity on the time-scale of minutes. E. J. Neurosci., 2004 DOI:

SJ Vayttaden, Mathuru AS and US Bhalla, A spectrum of models of signaling pathways. Chembiochem, 2004, DOI: 10.1002/cbic.200400127

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